Toxicity parameters of an acidic detergent-disinfectant based on orthophosphate acid with polyhexamethyleneguanidine

The sanitary condition of milking equipment and dairy is one the main factors on which quality and, primarily, safety obtained products depend. According to approved requirements, means for treatment must have a broad antimicrobial spectrum, high bactericidal activity both in absence presence organic substances water hardness salts, destroy microorganisms that can form biofilm, are present it, not cause an irritating effect skin hands, be non-toxic or low-toxic, etc. Therefore, establish disinfectant's compliance with specified even at stage its development, it envisaged carry out toxicological studies aimed determining toxicity, side effects, ability accumulate body. Our work toxicity parameters developed acidic detergent-disinfectant polyhexamethyleneguanidine intended sanitary-hygienic equipment. Indicators acute disinfectant were determined preliminary extensive experiments. In experiment, was established administration native remedy rats dose 500, 1000, 2000 mg/kg body weight did their death, while 5000 weight, caused death animals. studied based orthophosphate acid rats, 2500 1 animal, 3000 – 2 animals, doses 3500, 4000 4500 4, 5 6 respectively. Examining 0.5 % solution 2000, 3000, 4000, focused experiment 10000 extended there no dead sick rats. It has been proven that, according SOU 85.2-37-736:2011, substance under study belongs IV class, combines low-toxic substances, since DL50 white intragastric more than 3250 10,000 weight. form, causes slight irritation mucous membrane eyes rabbits. At concentration %, effect. tool does body, resorptive effect, probable changes mass internal organs. With long-term administration, increase number leukocytes, hemoglobin total protein, ALT, AST (P < 0.001) decrease lymphocytes, monocytes, lipids triglycerides, hematocrit value, alkaline phosphatase activity, lysozyme, activity.